As AI agents transform the workplace, organizations must adapt their structures and methodologies to harness new opportunities. The probabilistic nature of AI requires continuous iteration and intelligent oversight, creating new ways of working across business functions. To thrive, organizations must combine clear capability assessment with agile planning while leveraging their unique domain expertise and data assets. This keynote explores how leadership is evolving to meet these needs, covering new organizational models and roles that coordinate human-AI hybrid teams. Leaders will learn strategies for balancing rapid decision-making with strategic oversight, finding the optimal mix of centralized guidance and decentralized innovation.